Eine Frage ? Eine Beratung ?Unsere Mitarbeiter stehen zu Ihrer Verfugung, wenn Sie technische Fragen haben oder nur einfach eine Verfugbarkeit kennen mochten. Bitte rufen Sie uns an, ein deutschsprechender Kollege wird Ihnen beantworten.
This is the digital version of the printed book (Copyright 2008). Adrenaline junkies, dead fish, project sluts, true believers, Lewis and Clark, template zombies . . . Most developers, testers, and managers on IT projects are pretty good at recognizing patterns of behavior and gut-level hunches, as in, ´;I sense that this project is headed for disaster.´ But it has always been more difficult to transform these patterns and hunches into a usable form, something a team can debate, refine, and use. Until now. In Adrenaline Junkies and Template Zombies, the six principal consultants of The Atlantic Systems Guild present the patterns of behavior they most often observe at the dozens of IT firms they transform each year, around the world. The result is a quick-read guide to identifying nearly ninety typical scenarios, drawing on a combined one-hundred-and-fifty years of project management experience. Project by project, you´ll improve the accuracy of your hunches and your ability to act on them. The patterns are presented in an easy-reference format, with names designed to ease communication with your teammates. In just a few words, you can describe what´s happening on your project. Citing the patterns of behavior can help you quickly move those above and below you to the next step on your project. You´ll find classic patterns such as these: News Improvement Management by Mood Ring Piling On Rattle Yer Dags Natural Authority Food++ Fridge Door and more than eighty more! Not every pattern will be evident in your organization, and not every pattern is necessarily good or bad. However, you´ll find many patterns that will apply to your current and future assignments, even in the most ambiguous circumstances. When you assess your situation and follow your next hunch, youll have the collective wisdom of six world-class consultants at your side.
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Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum ) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l -physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a ´´lead compound´´) have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial. Physostigma venenosum is distributed throughout equatorial West Africa and having a colourful history - by virtue of their former use as an ordeal poison in trials for witchcraft in the Efik society of Old Calabar - are its dried ripe seeds (Calabar beans). The major toxic compound isolated from these, l -physostigmine, which is also known as eserine and is the only alkaloid as yet also to be isolated from a microbial source (along with l -N (8) -norphysostigmine) and is the first alkaloid found to contain a 1,2,3,3a,8,8a-hexahydropyrrolo[2,3- b ]indole ring system, and the first natural product found to contain a carbamyl group. It also became one of the first examples whereby the mechanism of action of a drug could be defined at the molecular level relatively simply, played a crucial role in the Nobel Prize - winning discovery of the mechanism of neurohumoral transmission, and has led to products for the treatment of a wide range of disorders associated with deficiencies in cholinergic transmission. Several other alkaloids have also been isolated from the Calabar bean. For some of these, structures have been established, syntheses effected and pharmacology investigated.